What percent of the population has Charcot-Marie-Tooth disease?

The prevalence of CMT disease is 1 person per 2500 population, or about 125,000 people in the United States. The incidence of CMT 1 is 15 persons per 100,000 population; the incidence of CMT 1A is 10.5 persons per 100,000 population, or 70\% of CMT 1.

Is Charcot-Marie-Tooth more common in males or females?

Because of this, we most likely can rule out this pattern in my family. X-linked CMT is the second-most common form of the disease. It seems that males with X-linked CMT show more severe signs then women.

Is Charcot-Marie-Tooth debilitating?

Since childhood, Ryan has contended with the debilitating—and initially mystifying—symptoms of Charcot-Marie-Tooth (CMT) disease, a neurological disorder that typically affects the nerves and muscles in the feet, causing varying degrees of pain, deformity and disability.

Can Charcot-Marie-Tooth skip a generation?

CMT does not skip generations genetically. For people with autosomal dominant and X-linked conditions, a person will either have the condition or not. If a parent has CMT that has been genetically confirmed, a child can be tested when that child is at least 18 years of age and with appropriate genetic counseling.

Is Charcot-Marie-Tooth the same as muscular dystrophy?

No, CMT is not a type of muscular dystrophy. CMT is primarily a disease of the peripheral nerves, whereas muscular dystrophy is a group of diseases of the muscle itself. CMT causes weakness and impaired sensory perception because signals can’t get to and from the brain to muscle and skin, among other things.

How do you inherit Charcot-Marie-Tooth disease?

Autosomal dominant inheritance of CMT occurs when 1 copy of a mutated gene is enough to cause the condition. If either parent carries a faulty gene, there’s a 50\% chance the condition will be passed on to each child they have.

Does CMT cause hair loss?

Other symptoms People with CMT may experience tingling and burning sensations in their hands and feet, causing discomfort and sometimes pain. Their sense of touch and the ability to sense temperature changes are diminished. Some people with sensory loss have dry skin and hair loss in the affected area.

Is CMT a progressive?

The symptoms of CMT usually start to appear between the ages of 5 and 15, although they sometimes do not develop until well into middle age or later. CMT is a progressive condition. This means the symptoms slowly get worse, making everyday tasks increasingly difficult.

How do you inherit Charcot Marie Tooth disease?

What is Charcot-Marie-Tooth disease (CMT)?

Charcot-Marie-Tooth disease (CMT) is one of the most common inherited neurological disorders, affecting approximately 1 in 2,500 people in the United States. The disease is named for the three physicians who first identified it in 1886 – Jean-Martin Charcot and Pierre Marie in Paris, France,…

What is the life expectancy of someone with Charcot-Marie-Tooth disease?

Pain can range from mild to severe, and some people may need to rely on foot or leg braces or other orthopedic devices to maintain mobility. Although in rare cases, individuals may have respiratory muscle weakness, CMT is not considered a fatal disease and people with most forms of CMT have a normal life expectancy.

Are there alternative treatments for Charcot-Marie-Tooth disease?

Complementary therapies: Some people with Charcot-Marie-Tooth disease have found that alternative therapies—such as acupuncture, biofeedback, capsaicin, alpha-lipoic acid, or meditation—can help relieve symptoms.

What is the most common cause of CMT?

CMT2A, the most common axonal form of CMT, is caused by mutations in Mitofusin 2, a protein associated with mitochondrial fusion. CMT2A has also been linked to mutations in the gene that codes for the kinesin family member 1B-beta protein, but this has not been replicated in other cases.